Elizabeth Sparkle (Demi Moore) is staring down the barrel of her 50th birthday, and her Hollywood star has more than a few cracks—both literal and metaphorical. To make matters worse, the once-popular aerobics queen just overheard her sleazy, keyed-up boss (played with pure snake oil charm by Dennis Quaid) plotting her replacement. The network wants someone younger, fresher, tighter in spandex. Enter a shadowy black-market pharma company with a miracle drug, the titular Substance, promising to rewind crucial time on Elizabeth’s biological clock. The promise is…misleading. As she drinks down the sketchy elixir of youth, she doesn’t just regain her youthful glow—she begins to lose herself, piece by horrifying piece, to the younger version she thought she so badly wanted. Read More